puerperal sepsis
Conditions
Interventions
intrapartum azithromycin
post partum amoxicillinclavulanic acid plus metronidazole
Sponsors
self sponsored
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: • Women aged 15-49years • Booked at FTH Katsina and at term (37–42 weeks gestation) • Planned for spontaneous vaginal delivery • No known allergies to azithromycin, amoxicillin-clavulanate, or metronidazole • Provide informed consent
Exclusion criteria
Exclusion criteria: • Women undergoing planned caesarean section or assisted vaginal delivery • Presence of clinical infection at admission • Use of systemic antibiotics within 7 days prior to delivery • HIV-positive women • Preterm labour (<37 weeks) • Anaemia with packed cell volume of less than 30%. • Antepartum haemorrhage • Women with prolonged premature rupture of membranes (occurring for more than 24 hours) before the onset of labour • Women with medical disorders that are routinely given prophylactic antibiotics during labour (Sickle Cell Anaemia, Diabetes Mellitus, Cardiac disease) • Women with intrauterine fetal death
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of maternal genital infection within six weeks postpartum . | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcomes will include specific infections like endometritis, wound infection, pelvic abscess, mastitis, therapeutic use of antibiotics, readmission, admission to special care unit. Similarly for the neonate, neonatal sepsis, readmission, admission to Nicu, duration of hospital stays. Safety outcomes such as medication side effects such as nausea and vomiting, diarrhoea and allergy | — |
Countries
Nigeria
Contacts
Public ContactAdeoye Tolulope kola
consultant obstetrician and gynaecologist
Outcome results
None listed