Dexmedetomidine versus ketamine to assist propofol for laryngeal mask airway insertion during diagnostic hysteroscopy

Dexmedetomidine versus ketamine as adjuvants to propofol for laryngeal mask airway insertion in spontaneously ventilated adult female patients undergoing diagnostic hysteroscopy: a randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

PACTR

Registry ID

PACTR202605546376442

Enrollment

Registered

2026-05-28

Start date

2026-03-01

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

Dexmedetomidine and Propofol

Ketamine and Propofol

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Adult females aged 18 to 50 years. American Society of Anesthesiologists (ASA) physical status I or II. Body mass index (BMI) between 18.5 and 30 kg/m². Scheduled for elective diagnostic hysteroscopy. Ability to maintain spontaneous breathing

Exclusion criteria

Exclusion criteria: Anticipated difficult airway (e.g., Mallampati class III or IV, mouth opening <3 cm, thyromental distance <6 cm, or limited neck mobility). Increased risk of aspiration (full stomach or gastroesophageal reflux disease). Known hypersensitivity or contraindication to any of the study drugs. Pregnancy or lactation. Patients requiring operative hysteroscopy or procedures expected to exceed 30 minutes.

Design outcomes

Primary

Measure	Time frame
Laryngeal Mask Airway (LMA) insertion conditions as measured by the modified Muzi scoring system.	—

Secondary

Measure	Time frame
Hemodynamic changes, including Heart Rate (HR) and Mean Arterial Pressure (MAP).;Incidence of respiratory complications, specifically apnea (>20 seconds) or oxygen desaturation (SpO_2 <92%).;Total induction dose of Propofol (mg/kg) required for successful LMA insertion.;Time to reach target entropy values (State Entropy = 60 and the difference between Response and State Entropy = 10).;Recovery time and duration of Post-Anesthesia Care Unit (PACU) stay.	—

Measure

Time frame

Hemodynamic changes, including Heart Rate (HR) and Mean Arterial Pressure (MAP).;Incidence of respiratory complications, specifically apnea (>20 seconds) or oxygen desaturation (SpO_2 <92%).;Total induction dose of Propofol (mg/kg) required for successful LMA insertion.;Time to reach target entropy values (State Entropy = 60 and the difference between Response and State Entropy = 10).;Recovery time and duration of Post-Anesthesia Care Unit (PACU) stay.

—

Countries

Egypt

Contacts

Public ContactAmir Badr

Resident of Anesthesia

amirboroo@gmail.com201096974925

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Jun 29, 2026