Probiotic adjunctive therapy in children with severe malaria

Effects of Probiotic Saccharomyces Boulardii on Serum Interleukin-10 Levels, Parasite Count, Clinical Course and Outcome of Children with Severe Malaria In Benin City

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202605540438627

Enrollment

128

Registered

2026-05-28

Start date

2024-03-04

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malaria

Interventions

Oral PROBIOTIC SACCHAROMYCES BOULARDII and IV Artesunate

Intravenous Artesunate

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All children aged 6 months to 17 years Diagnosis of severe malaria, Parents consent to the study

Exclusion criteria

Exclusion criteria: Severe malaria with confirmed meningitis Severe malaria with culture-proven bacterial sepsis Severe malaria with acute gastroenteritis

Design outcomes

Primary

Measure	Time frame
serum Interleukin-10 level	—

Secondary

Measure	Time frame
Malarial parasite clearance rate;Duration of admission;Survival till hospital discharge	—

Countries

Nigeria

Contacts

Public ContactOA Nwogbe

Administrative Secretary Nigerian Institute of Medical Research

nimr_ibr@yahoo.com+2348023513399

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026