Circulatory System Group A beta Haemolytic Sptreptococcal Organisms and teh Heart Cardiology
Conditions
Interventions
Intramuscular Benzathine penicillin
Sponsors
Akintunde Adeseye Abiodun
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: -Enrolled in one of the selected secondary schools within proximity to the tertiary hospitals, -They must have a confirmed diagnosis of mild or moderate RHD. -They must be capable of attending monthly visits. -At enrollment, students must demonstrate cognitive capacity to assent. - Female students of childbearing potential must agree to avoid pregnancy during the trial. -The individual must not have initiated any alternative RHD prophylaxis regimen before enrollment
Exclusion criteria
Exclusion criteria: -Students with advanced RHD (Stage C or D) that requires immediate surgical or intensive clinical management rather than secondary prophylaxis. - known allergy to penicillin or any history of anaphylaxis to antibiotics. -Students with severe comorbidities likely to complicate prophylaxis or follow-up, e.g., kidney or liver disease, uncontrolled diabetes, or other serious chronic illnesses (e.g., active tuberculosis, immunodeficiency) - Students with cognitive impairment that preclude assent or reliable adherence. - Any student currently enrolled in another interventional trial, or who is or whose parents are unwilling or unlikely to comply with monthly visits.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of the study will be the proportion of participants in the oral antibiotics arm who progress to more advanced RHD compared to those in the BPG arm post intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are patient-reported outcomes (treatment acceptance, satisfaction, and health-related quality of life using Health Related Quality of Life Questionnaire, HRQoL), costs, and cost-effectiveness of oral antibiotics compared to intramuscular penicillin prophylaxis for RHD post intervention. | — |
Countries
Nigeria
Contacts
Public ContactAgnes Inyam
Research Officer. Dept of Physiology LAUTECH Ogbomoso
Outcome results
None listed