Early mobilisation combined with targeted protein nutrition to improve muscle strength and recovery in critically ill patients

Effect of Early Mobilization Combined with Targeted Protein Optimization on Muscle Preservation and Functional Outcomes in Critically Ill Patients: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202605512848730

Enrollment

132

Registered

2026-05-12

Start date

2026-05-11

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Musculoskeletal Diseases Nervous System Diseases Nutritional, Metabolic, Endocrine Critical care / ICU-acquired weakness Anaesthesia

Interventions

Early mobilization combined with targeted protein optimization

Standard ICU care

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Age = 18 years Invasive mechanical ventilation = 48 hours Expected ICU stay = 72 hours Hemodynamic stability compatible with mobilisation Enteral nutrition feasible

Exclusion criteria

Exclusion criteria: Contraindication to mobilisation Neuromuscular disease affecting baseline strength Severe malnutrition requiring specialized management Pregnancy Expected death within 24 hours Limitation of therapeutic effort

Design outcomes

Primary

Measure	Time frame
Incidence of ICU-acquired weakness, defined as a Medical Research Council (MRC) sum score <48, assessed at first awakening from sedation.	—

Secondary

Measure	Time frame
Quadriceps muscle thickness variation (ultrasound) ICU Mobility Scale at discharge FSS-ICU score Ventilator-free days at day 28 Duration of mechanical ventilation ICU length of stay ICU mortality Delirium incidence (CAM-ICU) Safety outcomes (feeding intolerance, metabolic complications, adverse events)	—

Countries

Tunisia

Contacts

Public ContactMariem Ben Abdallah

Medical Doctor

mariembenabdallah@gmail.com00216778931

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026