Evaluation of preoperative ultrasound-guided skin mapping and carbon injection versus wire localization of non-palpable malignant breast lesions

Evaluation of preoperative ultrasound-guided skin mapping and carbon injection versus wire localization of non-palpable malignant breast lesions: A randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202605474375486

Enrollment

Registered

2026-05-28

Start date

2021-09-04

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery

Interventions

Ultrasound guided skin mapping with peritumoral carbon injection

Ultrasound guided wire localization

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Female patients aged 18–60 years. Patients with non-palpable malignant breast lesions detected by mammography and/or ultrasound. Patients with complete or partial clinical response after neoadjuvant therapy. Patients scheduled for breast-conserving surgery.

Exclusion criteria

Exclusion criteria: Previous local breast radiotherapy. Diffuse microcalcifications. Inflammatory breast carcinoma. Multicentric breast lesions. Pregnant patients. Patients unfit for surgery or refusing participation.

Design outcomes

Primary

Measure	Time frame
Incidence of clear surgical margins and need for re-excision after breast-conserving surgery.	—

Secondary

Measure	Time frame
Incidence of patients with Calculated Resection Ratio (CRR) >2.;Optimum Resection Volume (ORV).;Actual Resection Volume (ARV).;Excess Resection Volume (ERV).;Calculated Resection Ratio (CRR).;Cosmetic outcome and patient satisfaction.;Incidence of procedure-related complications including wire dislodgement, migration, pneumothorax, vasovagal attacks, wire transection, retained foreign body, or skin tattooing.	—

Measure

Time frame

Incidence of patients with Calculated Resection Ratio (CRR) >2.;Optimum Resection Volume (ORV).;Actual Resection Volume (ARV).;Excess Resection Volume (ERV).;Calculated Resection Ratio (CRR).;Cosmetic outcome and patient satisfaction.;Incidence of procedure-related complications including wire dislodgement, migration, pneumothorax, vasovagal attacks, wire transection, retained foreign body, or skin tattooing.

—

Countries

Egypt

Contacts

Public ContactMohamed Attia

Department of General Surgery Faculty of Medicine Cairo University

Massabry1@cu.edu.eg000000000

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026