Sepsis in general Nervous System Diseases
Conditions
Interventions
Muscle ultrasonography and inflammatory biomarker assessment
Sponsors
Menofia University Faculty of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult patients aged = 18 years Both male and female patients Diagnosis of sepsis according to Sepsis-3 criteria within 24 hours of ICU admission (suspected or confirmed infection with an acute increase in SOFA score = 2) Expected ICU length of stay = 7 days Patients who are fully conscious, alert, and cooperative at the time of ICU-acquired weakness assessment Written informed consent obtained from the patient or legal representative
Exclusion criteria
Exclusion criteria: Age < 18 years ICU stay < 7 days Failure to achieve full recovery of consciousness Pre-existing neuromuscular disorders, neurological disease, spinal cord injury, or prior neurosurgical disease Inability to obtain adequate muscle ultrasound images Incomplete clinical or laboratory data Use of medications known to affect muscle strength, including: Corticosteroids Neuromuscular blocking agents Aminoglycoside antibiotics Certain chemotherapeutic agents
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation between muscle ultrasonography changes and inflammatory biomarkers with ICU-acquired weakness (ICU-AW) in septic patients, aiming to construct a predictive nomogram model for early diagnosis of ICU-AW. | — |
Secondary
| Measure | Time frame |
|---|---|
| Sequential Organ Failure Assessment (SOFA) score;Need for mechanical ventilation;Duration of mechanical ventilation (days);Length of ICU stay (days);ICU mortality | — |
Countries
Egypt
Contacts
Public ContactIslam Elnemr
Critical care resident
Outcome results
None listed