Respiratory
Conditions
Interventions
Immediate antibiotics plus supportive care
Supportive care with delayed antibiotic strategy
Sponsors
None
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - NYSC Corps Members presenting with uncomplicated URTI, defined as a short illness (lasting five days or less) characterised by symptoms such as sore throat, runny nose, nasal congestion, cough, or mild fever (temperature up to 38.5°C). - Participants had to be clinically stable with normal findings on chest examination, no warning signs, and stable vital signs, and they had to be able to provide consent and agree to follow-up.
Exclusion criteria
Exclusion criteria: - Clinical features suggesting complicated or high-risk infection requiring immediate antibiotics or higher-level care, including suspected pneumonia, severe exudative tonsillitis with high fever, respiratory distress, temperature exceeding 38.5°C, or significant dehydration. - Significant chronic respiratory or systemic illness such as asthma, COPD, or uncontrolled diabetes that could alter the course of URTI or increase risk. - Known immunocompromised status, including HIV or current immunosuppressive therapy. - Known allergy or contraindication to the study antibiotic. - Ongoing antibiotic treatment for the current illness or another concomitant infection requiring antibiotics. - Any other condition that, in the clinician’s judgement, made a delayed-antibiotic approach unsafe.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical recovery by Day 5, defined as complete symptom resolution with total symptom score of 0 at Day 5. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Complete symptom resolution at Day 3 - Where available, complete symptom resolution at Day 7 for participants still symptomatic at Day 5 - Antibiotic use within the first five days - Occurrence of complications or adverse outcomes, including suspected bacterial complications, prolonged or worsening illness requiring additional treatment, referrals, or hospitalisation - Adverse drug reactions attributed to antibiotics, such as gastrointestinal upset, rash, or allergic reactions | — |
Countries
Nigeria
Contacts
Public ContactChukwugemezu Ihechere
Outcome results
None listed