Circulatory System Surgery Cardiology Anaesthesia
Conditions
Interventions
Opioid sparing M group
Opoid based T group
Sponsors
Faculty of Medicine Mansoura University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adult patients of both genders, aged between 18 and 70 years 2. American Society of Anesthesiologists (ASA) physical status II and III 3. Elective mitral valve replacement surgery with cardiopulmonary bypass (CPB) time less than 1 hour
Exclusion criteria
Exclusion criteria: 1. Repeated (redo) cardiac surgery 2. Emergency cardiac surgery 3. Combined valve replacement and CABG surgery 4. Patients with the need for re-exploration surgery 5. Patients on high pre and/or intraoperative inotropic support 6. Impaired systolic function (ejection fraction 2) 8. Patients with uncontrolled diabetes mellitus (HbA1C > 8%) 9. Patients with renal impairment (serum creatinine > 2 mg/dL) 10. Patients with advanced hepatic impairment (Child-Pugh C) 11. Patients with advanced chronic obstructive pulmonary disease (COPD) 12. Body mass index (BMI) > 40 kg/m2 13. Pregnant patients 14. Known allergy to any of the medications that will be used in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The 24h postoperative opioid consumption | — |
Secondary
| Measure | Time frame |
|---|---|
| The time of tracheal extubation;Hemodynamic parameters (heart rate, systolic, diastolic and mean arterial blood pressures);Response and State Entropies (RE/SE);Cardiopulmonary bypass (CPB) time;Aortic cross-clamping time;Visual Analogue Scale (VAS);Intensive care unit (ICU) length of stay;Hospital length of stay;Incidence of side effects and complications | — |
Countries
Egypt
Contacts
Public ContactIbrahim Ibrahim Abdelbaser
II Abdelbaser
Outcome results
None listed