Effect Of Preanesthetic Melatonin Versus Pregabalin,Both Combined With Deep Serratus Plane Block In Patients Undergoing Modified Radical Mastectomy:A Randomized Controlled Study

Analgesic Effect Of Preanesthetic Melatonin Versus Pregabalin,Both Combined With Deep Serratus Plane Block In Patients Undergoing Modified Radical Mastectomy.A Randomized Controlled Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202604486822662

Enrollment

Registered

2026-04-20

Start date

2025-05-22

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

melatonin

Pregabalin

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: • Female patients aged 18–65 years. • ASA physical status I. • Scheduled for elective unilateral modified radical mastectomy

Exclusion criteria

Exclusion criteria: Known allergy to local anesthetics or any of the study drugs.[Attachment] • Local infection at the injection site.[Attachment] • Chronic pain disorders or opioid use. • Pregnancy. • BMI greater than 40 kg/m². • Psychotic disorders. • Bleeding disorder.

Design outcomes

Primary

Measure	Time frame
postoperative Numeric Rating Scale pain score .	—

Secondary

Measure	Time frame
Numeric Rating Scale pain scores at 0, 2, 4, 8, 12, and 24 hours after surgery, 24-hour morphine consumption, Ramsay sedation score, length of PACU stay, postoperative nausea and vomiting, dizziness, quality of recovery, anxiety score, patient satisfaction, SAPB-related adverse events, chronic postsurgical pain at 3 months, and pain-related function at 3 and 6 months	—

Countries

Egypt

Contacts

Public ContactMahmoud Alseoudy

Associate professor of Anesthesia

drs3ody.mansora@mans.edu.eg+201006224551

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026