Effect of Adding Hyaluronidase to Bupivacaine in Quadratus Lumborum Block as an Analgesic Technique for Laparoscopic Hernia Repair

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202603652164523

Enrollment

Registered

2026-03-17

Start date

2026-04-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery Anaesthesia

Interventions

Group Quadratus lumborum block

Group Quadratus lumborum block with hyaluronidase

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: • Patients aged between 25 and 50 years of either gender • ASA physical status I or II • Scheduled for unilateral ,or bilateral uncomplicated laparoscopic inguinal hernia repair

Exclusion criteria

Exclusion criteria: • BMI =35 kg/m² • ASA class III or above • Contraindications to regional anesthesia or study drugs

Design outcomes

Primary

Measure	Time frame
•VAS score 12 hours post operative	—

Secondary

Measure	Time frame
• Time to first request of analgesia • The success rate of QLB as an analgesic technique (defined as complete homogeneous loss of sensation after block using the Hollmen scale injecting bupivacaine alone versus bupivacaine with hyaluronidase. • Onset time of anesthesia. • Duration of analgesia; defined as VAS score < 3without rescue analgesia in the first 12 hours. • Hemodynamic variation. • Postoperative pain score and analgesic requirements on the first postoperative day. • Early mobilization	—

Measure

Time frame

• Time to first request of analgesia • The success rate of QLB as an analgesic technique (defined as complete homogeneous loss of sensation after block using the Hollmen scale injecting bupivacaine alone versus bupivacaine with hyaluronidase. • Onset time of anesthesia. • Duration of analgesia; defined as VAS score < 3without rescue analgesia in the first 12 hours. • Hemodynamic variation. • Postoperative pain score and analgesic requirements on the first postoperative day. • Early mobilization

—

Countries

Egypt

Contacts

Public ContactAhmed Mohamed Sonbol

assistant professor of anesthesia faculty of medicine mansoura university

M.o.f.nasr@gmail.com+201016007487

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026