The efficacy of ultra-sound guided intra-articular injection of bupivacaine, tenoxicam and corticosteroids on pain relief in chronic knee osteoarthritis

A Comparative study to evaluate the efficacy of ultra-sound guided intra-articular injection of bupivacaine, tenoxicam and corticosteroids on pain relief in chronic knee osteoarthritis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202602873595988

Enrollment

Registered

2026-02-23

Start date

2017-10-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Musculoskeletal Diseases Orthopaedics Anaesthesia

Interventions

US guided interaarticular injection of bupivacaine for chronic knee osteoarthritis

US guided interaarticular injection of tenoxicam for chronic knee osteoarthritis

US guided interaarticular injection of methylprednisilone for chronic knee osteoarthritis

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. male and female patients aged between 30 and 60 years. 2. pain (VAS) of more than 30 mm on the day of inclusion. 3. radiographic evidence of OA of the knee grade II OA. 4. chronic pain for at least 3 months prior to study entry (day 0). 5.Unsatisfaction with previous attempts at non-operative

Exclusion criteria

Exclusion criteria: 1. Patient refusal. 2. intra-articular knee injection (with any corticosteroid, NSAID or local anestetics) within the previous three months, 3. Bleeding or coagulation disorder. 4. history of trauma or neuropathic arthropathy. 5. Local skin infection or current other problem in the affected extremity. 6. allergy or hypersensitivity to any of the study medications. 7. Pregnancy and lactation. 8. Juvenile osteoarthritis. 9. Low back pain due to central cause.

Design outcomes

Primary

Measure	Time frame
to compare the therapeutic effect of intra-articular injection of tenoxicam in comparison to bupivacaine and methylprednisilone for management of knee pain in osteoarthritic patients as regard pain relief.	—

Secondary

Measure	Time frame
1.To compare between the groups regarding duration of each drug, side effects and total requirement of oral analgesic after first injection. 2.Maintenance of patients’ independence, improvement of function and reduction of disease progression.	—

Countries

Egypt

Contacts

Public ContactAhmed Mohamed Sonbol

Assistant Proffesor

dr.sonbol@gmail.com+21003735129

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026