Malaria Pregnancy and Childbirth Hypertensive disorders of pregnancy
Conditions
Interventions
Standard antenatal and obstetric care
Routine antenatal malaria assessments and placental examination
Sponsors
Noguchi Memorial Instititute for Medical Research University of Ghana
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: The target population to be included will be Pregnant women aged 18 years and above who present for routine antenatal visit at the study sites. The analysis will be restricted to women whose first antenatal visit is on or before 20 weeks of gestation. Women who voluntarily consent to participate in the study with a signed written informed consent, including agreeing to the relevant follow-up period and donation of placenta after delivery. Women who plan to schedule all their antenatal visits to the study facilities and report to the same facilities when unwell, except in emergencies.
Exclusion criteria
Exclusion criteria: - Women with pre-existing cardiovascular disease, kidney disease, diabetes, chronic hypertension, history of smoking and Infections such as HIV and hepatitis B will be excluded from the study. Women who will be unavailable during the study follow-up period. Women who are critically ill (intensive care unit admission and severely anaemic (Hb < 5.0 g/dL) according to the clinician’s recommendation will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main outcome is the occurrence/incidence of hypertensive disorders of pregnancy in relation to placental malaria. | — |
Secondary
| Measure | Time frame |
|---|---|
| changes in immune response in early pregnancy compared to the later development of hypertensive disorders of pregnancy in Plasmodium-exposed women | — |
Countries
Ghana
Contacts
Public ContactDorotheah Obiri
Noguchi Memorial Institute for Medical Research University of Ghana
Outcome results
None listed