Anaesthesia
Conditions
Interventions
Low dose Nebulize dexmedetomidine
High dose Nebulize dexmedetomidine
Sponsors
Alaa Eldin Abdel Sami Aiad
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adults (18–60 years), ASA I–II scheduled for elective AFOI (anticipated difficult airway), Able to provide informed consent and comply with study procedures
Exclusion criteria
Exclusion criteria: Significant cardiac, pulmonary, or hepatic/renal disease, allergy to dexmedetomidine or lidocaine, pregnancy, Current use of clonidine or other strong a2-agonists/antagonists, difficult mask ventilation history, or refusal.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemodynamic responses (MAP, HR) at: scope/tube insertion. | — |
Secondary
| Measure | Time frame |
|---|---|
| Procedure time ;Adverse events (bradycardia, hypotension, hypoxemia), nausea/vomiting, need for conversion to GA, agitation, oversedation/apnea, and bleeding or sore throat ;Recall of events at 2–6 h;Hemodynamic responses (MAP, HR) at baseline, post-nebulization, 1 min, and 5 min post-intubation.;Sedation: MOAA/S scale at T1, T2, T3, T4, T5.;Tolerance & Ease of Intubation ;Lowest SpO2 during procedure;Cough score | — |
Countries
Egypt
Contacts
Public ContactAml Salama
Professor of Family Medicine
Outcome results
None listed