High-Flow Nasal Cannula versus Non-Invasive Ventilation in Acute Cardiogenic Pulmonary Edema: A Pilot Randomized Controlled Trial

High-flow nasal cannula (HFNC) versus non-invasive ventilation (NIV) in adults with acute cardiogenic pulmonary edema: an open-label, parallel-group, pilot randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202601838076295

Enrollment

Registered

2026-01-14

Start date

2025-10-07

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Cardiology

Interventions

High flow nasal cannula

Non invasive ventilation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adults aged =19 years Clinical diagnosis of acute cardiogenic pulmonary edema (ACPE) Radiologic evidence consistent with pulmonary edema (chest X-ray) Respiratory distress/dyspnea requiring non-invasive respiratory support SpO2 =92% on conventional oxygen therapy Hemodynamically stable (no immediate need for invasive ventilation)

Exclusion criteria

Exclusion criteria: Immediate need for endotracheal intubation Severe hemodynamic instability (e.g., shock/need for high-dose vasopressors) Altered mental status (GCS =12) or inability to protect airway Facial trauma/abnormalities preventing mask/cannula fitting Active upper gastrointestinal bleeding or high aspiration risk Contraindications to NIV/HFNC as per local practice Pregnancy

Design outcomes

Primary

Measure	Time frame
Treatment failure within 24 hours of initiating the assigned intervention.	—

Secondary

Measure	Time frame
Respiratory rate ;Oxygen saturation ;Patient comfort score (VAS 0–10);ICU length of stay ;Hospital length of stay ;In-hospital all-cause mortality	—

Countries

Egypt

Contacts

Public ContactHanady Mohamed

Lecturer of Critical Care Medicine

hanadymhmmd@gmail.com+201068004428

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026