A Comparison of the Efficacy and Safety of the use of Mifepristone and Misoprostol versus Misoprostol alone for Induction of Labour at Term

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202601828465500

Enrollment

Registered

2026-01-05

Start date

2024-10-23

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy and Childbirth

Interventions

Study group A had mifepristone and Misoprostol for IOL

Study group B had Placebo and Misoprostol for IOL

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Cephalic presentation 2. Term pregnancy 3. Reassuring Biophysical Profile 4.Unfavourable cervix with Bishop's score < 6 5. Women who consented in participating in the study 6. Womwn in whom labour induction can be deferred for 24 h

Exclusion criteria

Exclusion criteria: 1. Non-vertex presentation 2. Antepartum haemorrhage 3. Previous uterine scar 4. Contraindications to vaginal delivery 5.Multiple pregnancies 6. Known hypersensitivity to Mifepristone or Misoprostol 7. Grandmultipara 8. Women with severe preeclampsia 9. Refusal to give consent

Design outcomes

Primary

Measure	Time frame
Primary outcome Induction to delivery interval. Secondary outcome measures, number of caesarean sections, maternal side effects like fever, diarrhoea, APGAR score at 5 min, need for NICU admission	—

Secondary

Measure	Time frame
Number of caesarean sections in each group, maternal sideeffects like fever, diarrhoea, uterine hyperstimulation, babys APGAR at 5 minutes, need for NICU admission	—

Countries

Nigeria

Contacts

Public ContactSamuel Ilikannu

Member Research and Ethical Committee

dr.ilikannu@gmail.com+2348038411984

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026