Iontophoresis versus manual massage for knee osteoarthritis

Efficacy of iontophoresis with glucosamine sulphate and menthol gel versus cross-friction massage in patients with knee osteoarthritis: a randomized controlled clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202601808824915

Enrollment

Registered

2026-01-12

Start date

2024-01-15

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Musculoskeletal Diseases

Interventions

Crossfriction massage with glucosamine sulphate and menthol gel

Iontophoresis with glucosamine sulphate and menthol gel

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: clinically and radiographically diagnosed with primary knee osteoarthritis

Exclusion criteria

Exclusion criteria: • Autoimmune or inflammatory arthropathies (e.g., rheumatoid arthritis, systemic lupus erythematosus, seronegative spondyloarthropathies, gout). • Arthropathies secondary to infection, malignancy, or trauma. • History of previous knee surgery or fracture. • Pregnancy. • Age below 18 years.

Design outcomes

Primary

Measure	Time frame
Pain intensity measured using the Visual Analogue Scale (VAS), and functional status assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), evaluated at baseline and after 12 weeks of intervention.	—

Secondary

Measure	Time frame
Radiographic knee joint parameters, clinical examination findings (swelling, tenderness, crepitus, range of motion), and quadriceps muscle strength	—

Countries

Egypt

Contacts

Public ContactNaylan Khalil

Physical Medicine Rheumatology and Rehabilitation Department Faculty of Medicine Alexandria University

naylanfayez55@gmail.com00201275373640

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026