Effects of Probiotic Supplementation on Persistent Digestive Symptoms, Quality of Life, and Nutrition in People with Celiac Disease: A Prospective Study

Impact of Probiotic Supplementation on Persistent Digestive Symptoms, Quality of Life, Anthropometric Parameters, and Nutritional Intake in Patients with Celiac Disease: A Prospective Interventional Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202601715242367

Enrollment

Registered

2026-01-13

Start date

2025-08-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Digestive System

Interventions

control

probiotic

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Eligible participants included : - adults aged 18 to 65 years with confirmed celiac disease diagnosis. - persistent gastrointestinal symptoms including abdominal pain or bloating and provided informed consent.

Exclusion criteria

Exclusion criteria: Exclusion criteria comprised: other gastrointestinal disorders (Crohn's disease, ulcerative colitis); history of major gastrointestinal surgery; severe systemic or autoimmune diseases; recent or ongoing use of probiotics, prebiotics, or supplements within four weeks before inclusion; pregnancy or breastfeeding; inability to follow study protocol; severe psychiatric or cognitive disorders; known allergies to probiotics or supplement ingredients; celiac disease diagnosis less than 6 months prior.

Design outcomes

Primary

Measure	Time frame
Gastrointestinal Symptom Rating Scale (GSRS)	—

Secondary

Measure	Time frame
Celiac Disease Quality of Life Scale (CD-QOL)	—

Countries

Tunisia

Contacts

Public Contactrym ben othman

associate professorfaculty of medicine of tunis

rym.benothman@fmt.utm.tn+21699907402

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026