Impact of sub-anaesthetic dose of ketamine versus ephedrine on post-spinal hypotension in caesarean delivery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202601658370518

Enrollment

100

Registered

2026-01-30

Start date

2024-02-25

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

ketamine

ephedrine

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: pregnant women aged 19 to 45 years term pregnancies (=37 weeks of gestation) who were scheduled for elective cesarean section under spinal anesthesia

Exclusion criteria

Exclusion criteria: pre-eclampsia, chronic hypertension, or cardiovascular disease, contraindications to regional anesthesia such as local infection or coagulopathy, a history of epilepsy, psychiatric illness that could impair communication, known hypersensitivity to ketamine, declined to give informed consent, or had an American Society of Anesthesiologists (ASA) physical status of class III or IV.

Design outcomes

Primary

Measure	Time frame
the incidence of hypotension following spinal anesthesia during cesarean section	—

Secondary

Measure	Time frame
the total dose of administered ephedrine, sedation scores assessed by the modified Ramsay sedation scale, and the newborns’ APGAR scores at 1 and 5 minutes.	—

Countries

Egypt

Contacts

Public ContactBasant Ehab

assistant lecturer

Basantehab143@gmail.com01000468127

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026