Effectiveness of prophylactic intravenous bolus of norephineprine for prevention of spinal induced hypotension duration cesarean section

Prophylactic intravenous administration of two different bolus doses of norepinephrine for prevention of spinal-induced hypotension among parturients undergoing elective cesarean section under spinal anesthesia at Dilla University Teaching Hospital, 2025: A double-blind randomized controlled trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

PACTR

Registry ID

PACTR202601624780954

Enrollment

Registered

2026-01-12

Start date

2026-01-30

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

Intervention group N6

Intervention group N4

Control group NC

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Parturients with singleton term pregnancy, age 18-40, and ASA class I and II

Exclusion criteria

Exclusion criteria: Exclusion criteria Parturients with contraindications to norepinephrine Hyperthyroidism or hypothyroidism Blood pressure >140/90 mmHg Pregnancy-induced hypertension, like pre-eclampsia and others Co-morbid conditions like neurological, cerebrovascular, cardiovascular, renal, and psychiatric diseases Fetal abnormalities and fetal macrosomia >4kg Morbidly obese patients (BMI>40 kg/m2)

Design outcomes

Primary

Measure	Time frame
The incidence of spinal-induced hypotension between the groups	—

Secondary

Measure	Time frame
The total requirement of intermittent rescue bolus doses of norepinephrine The time of first rescue dose requirement of norepinephrine The maternal adverse effects The fetal outcome (APGAR score at 1 and 5 minutes)	—

Countries

Ethiopia

Contacts

Public ContactTimsel Girma

Senior Anesthetist

timsikebron15@gmail.com+251944060952

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026