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Early versus delayed norepinephrine administration in septic shock: a prospective randomised controlled trial

Early versus delayed norepinephrine administration in septic shock: a prospective randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
PACTR
Registry ID
PACTR202601621025108
Enrollment
122
Registered
2026-01-27
Start date
2023-12-01
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Circulatory System

Interventions

Early Norepinephrine Group
Late Norepinephrine Group

Sponsors

Menoufia University Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1- Adult patients (Age more than 18 years old) 2- Presence of septic shock identified as the presence of confirmed or suspected infection with a positive qSOFA score (two or more of SBP less than 100 mmHg, respiratory rate (RR) 22 or more breath per minute, and Glasgow Coma Scale (GCS) of less than 15) together with hypotension and lactate more than 2 mmol/L.

Exclusion criteria

Exclusion criteria: 1- their date wasn’t complete. 2- They were transferred to another healthcare facility before completion of the study protocol. 3- They didn’t fulfil the predefined inclusion criteria.

Design outcomes

Primary

MeasureTime frame
The primary outcome was the in-hospital survival rate

Secondary

MeasureTime frame
the secondary outcome was the time to restoration of MAP of 65 mmHg, the lactate clearance within the first 6 h of admission (post-resuscitation lactate), resuscitation fluid volume required to restore MAP, incidence of AKI among treated patients.

Countries

Egypt

Contacts

Public ContactAbdelaziz Taalab

Professor of General Surgury

abdulazizfox@gmail.com00201223105553

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026