Digestive System HIV/AIDS Rotavirus infection Severe acute malnutrition
Conditions
Interventions
Modified ready to use therapeutic food and standard ready to use therapeutic food
This group will not receive any intervention
Sponsors
National Institute for Medical Research
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: This study will include; i. Children aged 6-36 months ii. Children with consent given by a caregiver older than 18 years. iii. Children with SAM, defined as MUAC125 mm v. Children with or without SAM who have received the two doses of ORV at age of 6 and 10 weeks, as documented on their clinic cards. vi. Children with or without SAM having stored stool and plasma samples
Exclusion criteria
Exclusion criteria: This study will exclude; i. Children unable to provide stool or blood samples for measuring markers of EE and ORV response respectively. ii. Children whose caregivers won’t consent for an HIV test. iii. Children already in care by non-government organisation, government or any other agency. iv. Children without SAM having moderate or severe comorbidities conditions e.g., cleft palate, cerebral palsy, hydrocephalous etc (BrightSAM excluded all children with SAM having other cormobidities e.g., cleft palate, cerebral palsy, hydrocephalous etc).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Association between environment enteropathy and oral rotavirus response | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess if the association of EE and ORV response among children aged 6-36 months is modified by SAM or HIV status | — |
Countries
United Republic of Tanzania
Contacts
Public ContactIbrahim Materego
National Institute for Medical Research
Outcome results
None listed