Anaesthesia
Conditions
Interventions
normal saline as placebo
dexmedetomidine
Sponsors
anesthesia intensive care and pain management department. faculty of medicine menoufia university egypt
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: • Patients who are scheduled for laparoscopic hysterectomy. • Age from 35 to 65 years old. • American Society of Anesthesiologists (ASA ) I-II. • Body mass index (BMI) from 18.5 to 25 kg/m2.
Exclusion criteria
Exclusion criteria: • Patient refusal to participate. • Inappropriate temporal window for transcranial Doppler (TCD) measurement, cerebrovascular disease and/or increased intracranial pressure. • Respiratory diseases (Restrictive or Obstructive). • Uncontrolled hypertension ( > 140/90) or vascular diseases. • Heart block, bradyarrthymia. • Patients on ß blockers. • Procedures lasting less than 90 minutes. • Patients whose CO2 pneumoperitoneum and trendelenburg position are interrupted or converted to open technique. • Patients who have a history of allergy to a2 agonists or to any of the study drugs. • Patients who have eye diseases. • Patients whose ultrasound scans or measurements fail to clearly show the structure of ONSD.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intracranial pressure ICP) measured using optic nerve sheath diameter (ONSD). | — |
Secondary
| Measure | Time frame |
|---|---|
| pulsatility index from transcranial doppler;• Mean arterial pressure (MAP). • Heart rate. ;• Duration of pneumoperitonium. • Duration of trendelenburg position. • Intraoperative blood loss. • The volume of administered fluids. • EtCO2. • Extubation time (minutes from switch off isoflurane until the patient fulfills the global and respiratory criteria for safe extubation as breathing with a minimum tidal volume of 7 ml/kg, ability to sustain 5 seconds head lift, sustained hand grip, sustained arm lift). • PACU discharge time in minutes. | — |
Countries
Egypt
Contacts
Public Contactkhaled gaballah
assistant professor
Outcome results
None listed