Challenges in septic shock in how to predict outcomes in patients with septic shock during initial fluid resuscitation using macrovascular and microvascular markers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202601464859670

Enrollment

Registered

2026-01-28

Start date

2024-11-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Circulatory System

Interventions

Standard septic shock management with initial fluid resuscitation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult patients (=18 years) Both sexes Diagnosed with septic shock according to Sepsis-3 criteria Admitted to the ICU and receiving initial fluid resuscitation

Exclusion criteria

Exclusion criteria: Pregnant females Patients in whom capillary refill time cannot be reliably assessed (e.g., Raynaud’s syndrome, severe hypothermia) Patients with active bleeding Patients with liver cirrhosis Patients with acute severe respiratory distress syndrome (ARDS) Patients requiring surgical intervention within the first 6 hours of admission

Design outcomes

Primary

Measure	Time frame
ICU mortality in patients with septic shock, and its association with macrovascular markers (mean arterial pressure, heart rate, central venous pressure), microvascular markers (capillary refill time, peripheral perfusion index), and metabolic markers (serum lactate level and lactate clearance) during initial fluid resuscitation.	—

Secondary

Measure	Time frame
ICU length of stay;Duration of mechanical ventilation	—

Countries

Egypt

Contacts

Public ContactSalah Mostafa

Resident Intensivist

salah.mo7amed35@gmail.com+201006221819

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026