Cancer Nutritional, Metabolic, Endocrine
Conditions
Interventions
Aerobic Danse Training Program
Usual care. No structured exercise
Sponsors
Jihen Khalfoun
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: - women aged between 18 to 65 years, - RH+ breast cancer (ER±/PR±), Her2- , - ECOG performance status 0–1; medical clearance for exercise - no known history of chronic respiratory, cardiac, or neuromuscular disease, - who had been diagnosed with non-metastatic (M0) breast cancer. -All had undergone initial surgery, completed chemotherapy and radiotherapy, and were receiving adjuvant hormone therapy (0 to 5 years) (aromatase inhibitor "Letrozole"). - Patients had to be able to participate in a moderate physical activity program, as assessed by a healthcare professional. - They were recruited from among women living in Greater Tunis - Participants also had to be available and committed to following the entire training program planned for the study.
Exclusion criteria
Exclusion criteria: - prior enrollment in a structured exercise program before the start of the study - current smoking - simultaneous participation in alternative or complementary treatments not supervised by the hospital's oncology or rehabilitation services - history or diagnosis of another cancer. - women under the age of 18 and over the age of 65
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Variation in NK cell subsets CD3?CD16?CD56? (cytotoxic NK cells), CD3?CD16?CD56? (regulatory NK cells) , NK cell degranulation by CD107a expression , Leptin receptor expression on NK cells by CD295 (Ob-R) marker for each group: normal weight, overweight patients, patients with obesity class 1, 2, and 3 | — |
Secondary
| Measure | Time frame |
|---|---|
| Anthropometric measurements: weight, height, fat mass, muscle mass, BMI, metabolic protein mass, basal metabolic rate, bone mineral density, intracellular water, extracellular water, fat/lean cardiac risk Questionnaire: quality of life and anxiety and depression scale for each group: normal weight, overweight patients, patients with obesity class 1, 2, and 3 | — |
Countries
Tunisia
Contacts
Public ContactHaifa Rachdi
Associate Professor in the Medical Oncology Department at Abderrahmane Mami Hospital. Ministry of Health
Outcome results
None listed