Sepsis Paediatrics
Conditions
Interventions
Diagnostic Blood Tests for Sepsis CBC CRP PCT Blood Culture
Diagnostic Blood Tests for Non Septic Conditions CBC CRP PCT Blood Culture
Sponsors
Assiut University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Pediatric patients aged 1 month to 18 years Sepsis group cases diagnosed per International Pediatric Sepsis Consensus definitions Control group: age- and sex-matched children with minor infections or non-infectious conditions
Exclusion criteria
Exclusion criteria: Hematological disorders (leukemia, aplastic anemia, thrombocytopenia/neutropenia non-infectious) Immunocompromised status (chemotherapy, radiotherapy, corticosteroids, immunosuppressants, HIV, SCID) Chronic inflammatory or autoimmune diseases (juvenile idiopathic arthritis, lupus, IBD) Blood transfusion within 7 days prior testing Severe liver or renal disease affecting blood cells/inflammatory markers Missing key lab parameters for NLR/PLR calculation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic accuracy and statistically significant cut-off values for neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in identifying pediatric sepsis | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of diagnostic performance of NLR and PLR with traditional markers (CRP, procalcitonin) and assessment of their correlation with disease severity | — |
Countries
Egypt
Contacts
Public ContactMohamed Zakaria
Assiut University
Outcome results
None listed