Haematological Disorders
Conditions
Interventions
Blood sampling for telomerase measurement in transfusion dependent beta thalassemia patients
Blood sampling for telomerase measurement in healthy controls
Sponsors
Assiut University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Confirmed diagnosis of ß-thalassemia major Age 5-40 years Regular follow-up at thalassemia clinic =1 year Stable transfusion regimen (1 transfusion every 4-6 weeks, past 6 months) Consent obtained from participant or guardian
Exclusion criteria
Exclusion criteria: Recent malignancy or chemotherapy (past 12 months) Other chronic hematologic diseases Active/chronic infections or autoimmune diseases Bone marrow transplant or stem cell therapy history Use of antioxidant supplements (past 3 months) Pregnant or breastfeeding females Poor venous access or refusal to provide blood sample
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantification of Human Telomerase levels in transfusion-dependent beta thalassemia patients compared to healthy controls | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of telomere metrics with hematological indices such as hemoglobin, reticulocyte count, serum ferritin, and liver function among transfusion-dependent ß-thalassemia patients | — |
Countries
Egypt
Contacts
Public ContactEman Nasreldin
Assiut University
Outcome results
None listed