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Prophylactic carbetocin versus oxytocin for reducing intraoperative blood loss during caesarean section in women at high-risk of postpartum haemorrhage in Nnewi: A double-blind randomised controlled study

Prophylactic carbetocin versus oxytocin for reducing intraoperative blood loss during caesarean section in women at high-risk of postpartum haemorrhage in Nnewi: A double-blind randomised controlled study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
PACTR
Registry ID
PACTR202512762458292
Enrollment
218
Registered
2025-12-17
Start date
2025-12-22
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy and Childbirth

Interventions

OXYTOCIN
CARBETOCIN

Sponsors

Agbanu Chiemezie
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Grandmultiparity Multiple gestation Polyhydraminos Fetal macrosomia Uterine fibroid coexisting with pregnancy Previous caesarean section Prolonged labour Previous PPH

Exclusion criteria

Exclusion criteria: 1. Placental abruption (determined by history and ultrasound report) 2. Pre-eclampsia and Eclampsia 3. Previously documented Haematologic disorders of pregnancy e.g SCD, Thromophilias 4. Previously documented case of Cardiac diseases excluding Hypertension 5. Previously documented Renal diseases, 6. Previously documented Liver disease 7. Previously documented Epileptic 8. Moderate anemia (7-9gm/dl) 9. Known allergy to oxytocin or carbetocin 10. Low risk Pregnancies

Design outcomes

Primary

MeasureTime frame
The need for additional uterotonics

Secondary

MeasureTime frame
The mean postpartum blood loss ;The mean preoperative and postoperative haemoglobin change.;The proportion of women who will need a blood transfusion.;The proportion of women who will require additional surgical interventions (B-Lynch, uterine artery ligation, or hysterectomy).

Countries

Nigeria

Contacts

Public ContactChigozie Okafor

Consultant

chigolz@yahoo.com+2348034802657

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026