Respiratory Paediatrics
Conditions
Interventions
Point of care diagnostics package
Sponsors
Bernhard Nocht Institute for Tropical Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Consent/Assent to participate in the study. 2. 60 days to 15 years of age. 3. Admitted to hospital as per local clinician criteria under the diagnosis of Severe Acute Respiratory infection defined as: new onset ( 50 breaths/minute in children aged 2-11 months ii. > 40 breaths/min in children aged 12-60 months iii. > 30 breaths/min in children aged 5 - 12 years iv. > 20 breaths/min in adolescents aged 12 - 15 years
Exclusion criteria
Exclusion criteria: 1. Known Tuberculosis or a patient highly suspected at presentation 2. Aspiration Pneumonia (or highly suspected at presentation) 3. Hospital-acquired Pneumonia (48 hours or more after hospital admission) in the last 7 days prior to screening 4. Known lung abscess, cavern or empyema 5. Clinical suspicion of non-respiratory, primary source of infections with exception of malaria. 6. Critically ill patient when presenting to ED with signs of respiratory failure and indication for a. resuscitation b. current vasopressor use c. mechanical ventilation via endotracheal tube 7. Severe Immunosuppression a. Known Neutropenia (<1 leucocyte/mL or < 0.5 neutrophil/mL) b. Known HIV/AIDS with WHO clinical stage 4 disease or with CD4 < 200 cells/ml in children =6 years; < 500 cells/ml in children 1-5 years; < 750 cells/ml in children<12 months c. Severe malnutrition (kwashiorkor, marasmus (weight for height <-3 SD), severe stunting (height for age <-3SD)) 8. Known Malignancy a. Metastatic cancer 9. Immunosuppressive therapy a. Immunosuppressive drugs within the previous 30 days, including anti-cancer chemotherapy and anti-rejection drugs for organ/bone marrow transplant b. Systemic corticosteroids therapy 10. Chronic dialysis 11. Surgery in the past 7 days (excluding minor surgery such as skin biopsy) 12. Other respiratory conditions a. Tracheostomy b. Diffuse bronchiectasis, cystic fibrosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The sensitivity and specificity of a point-of-care diagnostic package in distinguishing viral from bacterial Severe Acute Respiratory Infection (SARI) amongst children aged 60 days to 15 years in a malaria-endemic setting in Africa. | — |
Secondary
| Measure | Time frame |
|---|---|
| Effect of malaria co-infection on the diagnostic performance of inflammatory biomarkers (e.g., C-reactive protein, procalcitonin);The impact of an antimicrobial stewardship (AMS) training program on antimicrobial use (AMU) and prescription practices at the study site;Exploratory. Characterizing the temporal pattens of inflammatory biomarkers throughout hospitalization and explore their potential to inform AMS actions;Exploratory. The frequency of Mycoplasma pneumoniae (Mp) causing SARI admission amongst children aged 60 days to 15 years at the St. Francis Xavier Hospital (SFXH) in Assin Foso, Ghana | — |
Countries
Ghana
Contacts
Public ContactRobin Kobbe
CoPrincipal Investigator BNITM
Outcome results
None listed