Evaluation of an Experimental Selenium Nanoparticle–Based In-Office Bleaching Gel in Heavy Coffee Consumers

Experimental in office Bleaching Gel Containing Selenium Nanoparticles as a Replacement for Hydrogen Peroxide in Heavy Dark Coffee Consumption Cases: A Randomized Clinical Trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

PACTR

Registry ID

PACTR202512690241493

Enrollment

Registered

2025-12-23

Start date

2025-03-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Health

Interventions

Commercial Bleaching Gel

Experimental Bleaching Gel

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adults aged 25–35 years. Good general and oral health. Fully erupted maxillary incisors and canines with no restorations. At least one maxillary anterior tooth with shade A3 or darker. Daily consumption of more than two cups of coffee (heavy coffee users). Able and willing to sign informed consent.

Exclusion criteria

Exclusion criteria: Presence of systemic diseases or oral mucosal disorders. Pregnant or breastfeeding women. Known allergy to any component of the bleaching products. Previous history of any tooth bleaching treatment. Ongoing orthodontic treatment.

Design outcomes

Primary

Measure	Time frame
Tooth colour change (?E) measured using a spectrophotometer.	—

Secondary

Measure	Time frame
Tooth sensitivity - VAS score;Gingival irritation - VAS score	—

Countries

Egypt

Contacts

Public ContactRiham Aly

Basic Dental Science Department . Oral and dental research institute. National Research Centre

Rm.el-sayed@nrc.sci.eg+201001651731

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026