Pregnancy and Childbirth Haemorrhage Anaesthesia
Conditions
Interventions
placebo
Sponsors
Dr Dauda Rahmat
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Singleton pregnancies 2. Gestational age 37-42 weeks on admission for Caesarean Section 3. No contraindication to Melatonin 4. No contraindication to spinal anaesthesia
Exclusion criteria
Exclusion criteria: 1. Known allergy to Melatonin 2. History of use of psychotropic medications 3. Pain perception disorders, such as hyperalgesia 4. Hepatic and renal dysfunction. 5. Current Melatonin therapy 6. Previous postpartum haemorrhage 7. Antepartum haemorrhage 8. Polyhydramnios 9. Coexisting uterine fibroids 10.Prior history of thrombo-embolism and bleeding disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Mean blood loss at caesarean section in participants. 2. Percentage of participants with mild, moderate, and severe postoperative pain scores. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Percentage of participants who developed PPH. 2. Mean pre- and post-operative differential haemoglobin level in participants. 3. Percentage of participants with low postoperative hemoglobin levels 4. Percentage of participants who required rescue analgesia 5.Percentage of participants with low APGAR score. | — |
Countries
Nigeria
Contacts
Public ContactAdebiyi Gbadebo Adesiyun
Professor consultant
Outcome results
None listed