Respiratory
Conditions
Interventions
Sponsors
Menoufia University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1- Patients with AECOPD with moderate hypercapnic respiratory failure(pH ranges between 7.25 and 7.35 and a PaCO2 = 50 mmHg). 2 - The patient should be conscious, alert, and cooperative.
Exclusion criteria
Exclusion criteria: 1- Age 0.5). 4 - Significant hypercapnia with pH = 7.20. 5- Severe dyspnea (RR = 40 breaths/min). 6- Glasgow coma score < 8. 7- Contraindications to NIV or HFNC As: A- Poor sputum excretion ability. B- Oral or facial trauma. C- Significant hemodynamic instability. D- Poor short-term prognosis (those already receiving palliative care or at very E -high risk of death within seven days due to existing medical/surgical pathology). F- Presence of a tracheostomy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of the treatment failure rate (which is defined as invasive ventilation or a switch in respiratory treatment modality). | — |
Secondary
| Measure | Time frame |
|---|---|
| Analysis of the following data: • ICU mortality. • ICU length of stay. • Timing of intubation. • The duration of respiratory support. • Arterial blood gas analysis (pH, PaCO2, and PaO2/FiO2) and vital signs (RR, heart rate, and blood pressure). | — |
Countries
Egypt
Contacts
Public ContactRabab Mohammed Habeeb
Assistant professor of anesthesiology and intensive care. Faculty of medicine. Menoufia University
Outcome results
None listed