The AFRICARhE project: the African Initiative for Rh disease Eradication

Eradication of Hemolytic Disease of the Fetus and Newborn in Africa through screening and prevention

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202511839072355

Enrollment

20500

Registered

2025-11-03

Start date

2025-09-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Haematological Disorders Pregnancy and Childbirth Hemolytic disease of the Fetus and Newborn / Rh disease

Interventions

Screening of HDFN

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: For Ethiopia and Tanzania: every women > 18 years and pregnant For Malawi: neonates

Exclusion criteria

Exclusion criteria: n/a

Design outcomes

Primary

Measure	Time frame
To investigate the prevalence, risk factors, and clinical outcomes related to RhD negative status and RhD alloimmunization, HDFN burden, evaluate the effectiveness of preventative measures, and assess the knowledge, awareness, practices, and perspectives of pregnant women in selected healthcare facilities in Tanzania, Ethiopia and Malawi.	—

Secondary

Measure	Time frame
To determine the prevalence of RhD negativity among pregnant women among selected health facilities in Tanzania and Ethiopia To determine the prevalence of RhD alloimmunization among pregnant women among selected health facilities in Tanzania and Ethiopia To identify the factors associated with RhD alloimmunization among RhD-negative pregnant women among selected health facilities in Tanzania and Ethiopia To assess the perinatal outcomes of RhD-negative pregnancies complicated by anti-D) alloantibodies among selected health facilities in Tanzania, Malawi and Ethiopia To evaluate the knowledge of pregnant women about the clinical management of hemolytic disease of the fetus and newborn among selected health facilities in Tanzania and Ethiopia To assess the knowledge, attitudes, and practices (KAP) of obstetric care providers concerning maternal RBC alloimmunization among selected health facilities in Tanzania and Ethiopia To describe women’s experiences of a pregnancy complicated by RBC alloimmunization among selected health facilities in Tanzania, Malawi and Ethiopia To study the causes of neonatal jaundice in Malawi	—

Measure

Time frame

To determine the prevalence of RhD negativity among pregnant women among selected health facilities in Tanzania and Ethiopia To determine the prevalence of RhD alloimmunization among pregnant women among selected health facilities in Tanzania and Ethiopia To identify the factors associated with RhD alloimmunization among RhD-negative pregnant women among selected health facilities in Tanzania and Ethiopia To assess the perinatal outcomes of RhD-negative pregnancies complicated by anti-D) alloantibodies among selected health facilities in Tanzania, Malawi and Ethiopia To evaluate the knowledge of pregnant women about the clinical management of hemolytic disease of the fetus and newborn among selected health facilities in Tanzania and Ethiopia To assess the knowledge, attitudes, and practices (KAP) of obstetric care providers concerning maternal RBC alloimmunization among selected health facilities in Tanzania and Ethiopia To describe women’s experiences of a pregnancy complicated by RBC alloimmunization among selected health facilities in Tanzania, Malawi and Ethiopia To study the causes of neonatal jaundice in Malawi

—

Countries

Ethiopia, Malawi, Tanzania

Contacts

Public ContactTienke Vermeiden

PhD

africarhe@lumc.nl+31715260900

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026