Anaesthesia
Conditions
Interventions
Magnesium sulfate
Dexmedetomidine
Sponsors
Mario Ragaey Fakhry Doos
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: • Age: 19 to 65 years. • ASA physical status I or II • Scheduled for elective craniotomy requiring skull pinning (brain tumors (e.g., meningioma, glioma), Aneurysm clipping, and Elective craniotomy for chronic subdural or extradural hematomas). • Hemodynamically stable preoperatively (MAP 65–100 mmHg, HR 60–100 bpm)
Exclusion criteria
Exclusion criteria: • Surgeries not involving skull pinning • ASA III or higher • Known allergy or contraindication to dexmedetomidine or magnesium sulfate • Severe cardiac, renal, or hepatic dysfunction • Use of beta-blockers, calcium channel blockers, or other agents affecting autonomic tone • Pregnancy or lactation • History of brady arrhythmia, heart block, or seizure disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the efficacy of magnesium sulfate and dexmedetomidine in attenuating hemodynamic responses mean arterial pressure during skull pin application in patients undergoing elective craniotomy under general anesthesia | — |
Secondary
| Measure | Time frame |
|---|---|
| the efficacy of magnesium sulfate and dexmedetomidine in attenuating hemodynamic response heart rate | — |
Countries
Egypt
Contacts
Public ContactMario Ragaey Fakhry Doos
Resident of Anesthesia Intensive Care and Pain Management. Assiut University Hospital
Outcome results
None listed