Cancer Circulatory System Anaesthesia
Conditions
Interventions
Pregabalin
Melatonin
Placebo
Sponsors
Cairo University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: • Female patients • Type of surgery; Abdominal hysterectomy • American Society of Anesthesiologists (ASA) physical status II, III. • Age = 18 and = 65 Years. • Body mass index (BMI): > 20 kg/m2 and < 35 kg/m2.
Exclusion criteria
Exclusion criteria: • Patient refusal. • Age 65 years • Body mass index (BMI) 35 kg/m2 • Known sensitivity or contraindication to drugs used in the study (pregabalin, melatonin, opioids). • History of psychological disorders and/or chronic pain, and/or sleep disorders. • Patients receiving medications that are considered to result in tolerance to opioids as those who are receiving medications for cancer pain (e.g. tramadol and hydromorphone). • Significant liver insufficiency (liver enzymes more than two folds or severe liver cirrhosis) or renal insufficiency (plasma creatinine more than 1.5 mg/dl). • Severe respiratory disorders (e.g. Chronic obstructive pulmonary disease, Bronchial asthma) or cardiac disorders (e.g. ischemic heart disease, regional motion wall abnormality, EF< 50%). • Anticipated difficult intubation, those requiring more than one attempt or more than 20 sec for laryngoscopy. • Uncontrolled diabetes or uncontrolled hypertension. • Physical status American Society of Anesthesiologists (ASA) physical status IV and Male patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in heart rate | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in blood pressure ;Change in serum cortisol level ;Degree of postoperative sedation according to Ramsay scores;Postoperative nausea and vomiting (PONV);Incidence of adverse effects | — |
Countries
Egypt
Contacts
Public ContactHossam ;Essam Ghoprial;Mahran
Professor ;Assistant Professor
Outcome results
None listed