Guillain-Barré Syndrome: Relative Frequency of Different Variants, Relationship to Gut Dysbiosis, and Clinical Outcome

A prospective observational study evaluating the relative frequency of Guillain-Barré Syndrome variants and their relationship to gut dysbiosis and clinical outcomes in Egyptian patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202511690780998

Enrollment

Registered

2025-11-17

Start date

2026-01-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nervous System Diseases

Interventions

Clinical and microbiological assessment

Clinical assessment

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: • Adults =18 years old. • Diagnosed with GBS according to NINDS and Brighton Collaboration criteria. • Admitted within 2 weeks from symptom onset. • Able to provide stool samples within 48 hours of admission.

Exclusion criteria

Exclusion criteria: • Chronic gastrointestinal disease (IBD, celiac disease, chronic diarrhea). • Recent use (within 4 weeks) of antibiotics, probiotics, or immunosuppressive therapy. • Other acute neurological diseases mimicking GBS.

Design outcomes

Primary

Measure	Time frame
.Determine the relative frequency of Guillain-Barré Syndrome variants (AIDP, AMAN, AMSAN,Miller’s fissure,	—

Secondary

Measure	Time frame
2-To compare gut microbiota composition between GBS patients and age-/sex-matched healthy controls. 3-To evaluate the association between gut microbiota characteristics and specific GBS variants. To assess the relationship between gut microbiota profiles and functional outcomes at 4 weeks and 6 months	—

Countries

Egypt

Contacts

Public ContactNourelhoda Haridy

Dr at Neurology and psychiatry department Assiut university hospital

nourelhodaahmed@aun.edu.eg+201063981139

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026