Clinicolaboratory Predictors of Outcome in children with encephalitis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202511599646362

Enrollment

Registered

2025-11-24

Start date

2026-01-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nervous System Diseases Paediatrics

Interventions

CSF Sample

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. patients aged 1 year to 18 years with manifestation of encephalitis • Decreased level of consciousness, personality change, or psychiatric manifestations lasting >24 h (in toddlers and infants, may present as increased irritability or lethargy) • No alternative diagnosis to explain presentation • Seizure (new onset) • Fever (=38.0°C) • Focal neurologic findings (new onset) • CSF WBC =5/mm3 • Acute abnormality on brain MRI as cerebillitis or white mater affection causing motor deficit

Exclusion criteria

Exclusion criteria: 1. If they had a diagnosis of delirium or encephalopathy secondary to renal, hepatic, toxins or metabolic causes (hypoglycemia, electrolyte disturbances)

Design outcomes

Primary

Measure	Time frame
To assess clinical, radiological laboratory biomarkers (CSF Neuron-Specific Enolase and S100B) as outcome predictors of encephalitis	—

Secondary

Measure	Time frame
Role of CSF Neuron-Specific Enolase and S100B in diagnosis of encephalitis in children and their correlation with clinical and neuroimaging	—

Countries

Egypt

Contacts

Public ContactMahmoud Abdelfattah

Lecturer

mahmoudabdelfattah@aun.edu.eg+201003023766

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026