Combined Letrozole and Clomiphene citrate versus Letrozole and gonadotropin protocol for ovulation induction in infertile clomiphene-resistant women with polycystic ovary syndrome

Comparison between Combined Letrozole and Clomiphene citrate versus Letrozole and gonadotropin protocol for ovulation induction in infertile clomiphene-resistant women with polycystic ovary syndrome

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202511544935228

Enrollment

100

Registered

2025-11-03

Start date

2022-12-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nutritional, Metabolic, Endocrine Fertility-female

Interventions

Letrozole and Clomid

Letrozole

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: • Clomiphene citrate-resistant 1ry infertile polycystic ovary syndrome (PCOS) patients • Women who are = 35 years old. • Other normal diagnostic workup of infertility, including: Semen analysis, ultrasound examination, other than PCOS, and hysterosalpingogram.

Exclusion criteria

Exclusion criteria: The presence of any other infertility factors including:- • Thyroid dysfunction • Hyperprolactinemia • Endometriosis • Pelvic inflammatory disease (PID) • Single ovarian cyst in the same cycle History of ovarian hyperstimulation

Design outcomes

Primary

Measure	Time frame
Ovulation rate	—

Secondary

Measure	Time frame
Number of mature follicles;Serum E2 ;Endometrial thickness ;Rate of occurrence of pregnancy;Incidence of complications	—

Countries

Egypt

Contacts

Public ContactHesham Salem

Professor

hesham.salem@med.tanta.edu.eg00201223488672

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026