Study on Sickle Cell Leg Ulcer Treatment

Comparing The Wound Healing Rate Of Sickle Cell Leg Ulcers In Patients Treated With Platelet Rich Plasma(PRP) and Povidone Iodine Dressing – A Randomised Controlled Study.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202511489399574

Enrollment

Registered

2025-11-17

Start date

2025-01-06

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Haematological Disorders Skin and Connective Tissue Diseases Surgery

Interventions

Povidone iodine dressing

Platelet rich plasma aka PRP

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. All patients living with sickle cell disease and living with an ulcer more than 2 months old. 2. All consenting patients living with sickle cell disease and living with an ulcer.

Exclusion criteria

Exclusion criteria: 1. Patients with sensory loss in the leg. 2. Patients with uncontrolled diabetes and HIV/AIDS

Design outcomes

Primary

Measure	Time frame
Time to healing and rate of epithielisation	—

Secondary

Measure	Time frame
1. Change in the plasma levels of wound healing factors - tumour necrosis factor alpha, interleukin 6,Fibroblast growth factor, vascular endothelial growth factor, epidermal growth factor, platelet derived growth factor, interleukin 10, Transforming growth factor alpha. 2. Change in plasma levels of Nitric oxide	—

Countries

Nigeria

Contacts

Public ContactFrank Akpuaka

Emeritus Professor

frankakpuaka@yahoo.com+2348182229255

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026