Neonatal Diseases
Conditions
Sponsors
Faculty of Medicine Menoufia University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Preterm neonates (<37 weeks) of both sexes 2. Neonates diagnosed with respiratory distress syndrome clinically and radiologically. a) Clinical respiratory distress was defined as respiratory effort within the first 24 hours after birth, characterized by at least two of the following: tachypnea, chest retraction, grunting, or cyanosis. b) Radologically diagnosed by chest X-ray findings include fine homogeneous ground glass shadowing, bilateral widespread air bronchogram, confluent alveolar shadowing obscuring the cardiac border, and white lung.
Exclusion criteria
Exclusion criteria: (1) Neonates requiring intubation in the delivery room and invasive mechanical ventilation within the first 24 hours (2) Congenital anomalies where CPAP and Hi-VNI are contraindicated (such as choanal atresia, tracheoesophageal fistula, congenital diaphragmatic hernia, gastroschisis) (3) Neonates transferred to other NICUs during management.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the efficacy and safety of High Velocity Nasal Insufflation Hi-VNI compared to nasal Continuous Positive Airway Pressure CPAP as an initial respiratory support in preterm neonates with Respiratory Distress Syndrome | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the other clinical outcomes as well as complications associated with the use of the intervention. | — |
Countries
Egypt
Contacts
Public ContactMohamed Abdelkader Alkenawy
Neonatology resident
Outcome results
None listed