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Intrathecal Isobaric Versus Hyperbaric Bupivacaine Anesthesia with Dexmedetomidine in Ureteroscopy: A Cardiac Output and Hemodynamic window. Randomized Controlled Trial

Intrathecal Isobaric Versus Hyperbaric Bupivacaine Anesthesia with Dexmedetomidine in Ureteroscopy: A Cardiac Output and Hemodynamic window. Randomized Controlled Trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
PACTR
Registry ID
PACTR202510870626454
Enrollment
78
Registered
2025-10-08
Start date
2024-07-01
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Circulatory System Anaesthesia

Interventions

Isobaric Group

Sponsors

Mansoura University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: • Patients, American Society of Anesthesiologists physical status (ASA) I, II • Age from 18 to 70 years • Both sexes • Body mass index from = 35 Kg/m2

Exclusion criteria

Exclusion criteria: o Patient Refusal o Local Infection at site of insertion o Hematological disorders e.g. Hemophilia or other Bleeding diathesis (INR > 1.6, Prothrombin < 60% or Platelets < 70.000) o Known intolerance to the study drugs. o Uncontrolled Psychiatric diseases as psychosis or disorders with psychotic features o Spinal Deformities or Neuromuscular diseases o Any other contraindications to neuraxial block e.g. severe cardiac valve disease, acute myocardial Ischemia, severe pulmonary hypertension or Bronchial asthma Exacerbation.

Design outcomes

Primary

MeasureTime frame
Cardiac Index (CI) Measurements

Secondary

MeasureTime frame
1. Intraoperative measurement of systolic time ratio (STR), delivery of oxygen (DO2) based on hemoglobin and oxygen saturation, systemic vascular resistance (SVR), cardiac output (CO), mean arterial blood pressure (MAP), heart rate (HR) 2. Time needed to reach the level of anesthesia at T5. 3. Time of 2-Segment Regression i.e. the time needed for the level of anesthesia to decline by two levels. 4. Intravenous Fluids given all over the operation 5. Time needed for first analgesic request i.e. time interval between spinal anesthesia and patient first complaint of pain requiring analgesia (Visual Analogue Score > 3)

Countries

Egypt

Contacts

Public ContactKareem Awad

Lecturer of Anesthesia

Dr.karimali2010@mans.edu.eg00201004209702

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026