Neuromuscular fatigue regulation and metabolic disorders during exercise in patients with type 1 diabetes

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202510823123375

Enrollment

Registered

2025-10-20

Start date

2025-10-01

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nutritional, Metabolic, Endocrine

Interventions

Type 1 diabetes group

Healthy control group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: : 18-35 years old, diabetic with T1D for at least 3 years and glycosylated hemoglobin (HbA1c) <10 (%) for the last six months before entering the study.

Exclusion criteria

Exclusion criteria: significant diabetic complications limiting exercise (diabetic foot, retinopathy, severe neuropathy), uncontrolled hypertension, diabetic ketoacidosis (DKA), severe hypoglycemia in the last three months, patients on lipid-lowering therapy.

Design outcomes

Primary

Measure	Time frame
Neuromuscular function assessment of the quadriceps, including maximal voluntary contraction, potentiated twitch , vlonutary activation, Electromyography of vastus lateralis (VL) and the vastus medialis (VM) and rectus femoris (RF) muscles. Please, note that those parameters were evaluated only once ( and not before and after intervention because there is no intervention in this project. Our study compared those outcomes between type 1 diabetes and healthy controls.	—

Measure

Time frame

Neuromuscular function assessment of the quadriceps, including maximal voluntary contraction, potentiated twitch , vlonutary activation, Electromyography of vastus lateralis (VL) and the vastus medialis (VM) and rectus femoris (RF) muscles. Please, note that those parameters were evaluated only once ( and not before and after intervention because there is no intervention in this project. Our study compared those outcomes between type 1 diabetes and healthy controls.

—

Secondary

Measure	Time frame
Glycemia, Insulin, cortisol	—

Countries

Tunisia

Contacts

Public ContactAmal Machfer

University of sfax

amalmachfer@gmail.com0021697687655

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026