Effectiveness of preoperative Tranexamic acid versus placebo on blood loss in high-risk postpartum haemorrhage women undergoing caesarean section at Ahmadu Bello University Teaching Hospital, Zaria; A Randomized Controlled trial

Effectiveness of preoperative Tranexamic acid versus placebo on blood loss in high-risk women undergoing caesarean section at Ahmadu Bello University Teaching Hospital, Zaria; A Randomized Controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR202510738673777

Enrollment

124

Registered

2025-10-30

Start date

2025-12-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

high-risk postpartum haemorrhage women undergoing caesarean section

Interventions

placebo

Tranexamic acid

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: All consenting women with the following: Previous history of PPH Previous caesarean section Coexisting uterine fibroid Macrosomia Polyhydramnios Placenta praevia Mild abruptio placentae Multiple pregnancy Preeclampsia Eclampsia Failed induction or augmentation of labour Placenta accreta spectrum

Exclusion criteria

Exclusion criteria: Disseminated intravascular coagulopathy Known allergy to tranexamic acid

Design outcomes

Primary

Measure	Time frame
Mean blood loss in both arms of the study during surgery, up to 24 hours after surgery	—

Secondary

Measure	Time frame
The proportion of women who will need blood transfusion in both arms of the study. The proportion of women in both arms who will require additional uterotonic(s) and surgical interventions. Proportion of primary PPH in both arms of the study after surgery Proportion of postpartum maternal anaemia in both arms of the study after surgery	—

Countries

Nigeria

Contacts

Public ContactFaiza Bello

Postgraduate student

faizabello95@gmail.com+2347039498495

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026