Effect of Vitamin C and Zinc with Antibiotics Accelerates Recovery in Community-Acquired Bacterial Pneumonia

Adjunctive Vitamin C and Zinc with Antibiotics Accelerates Recovery in Community-Acquired Bacterial Pneumonia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

PACTR

Registry ID

PACTR202510702581284

Enrollment

Registered

2025-10-06

Start date

2024-06-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory

Interventions

Vitamin c and zinc in combination with antibiotics

Antibiotics only

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: age between 18 and 59 years, newly diagnosed typical bacterial pneumonia, productive cough, not receiving antibiotics before enrollment, and agreement to participate.

Exclusion criteria

Exclusion criteria: Exclusion criteria: age 60 years, history of chronic respiratory or systemic diseases, immunodeficiency, other concurrent infections requiring antibiotics, recent (within 48 h) use of vitamin C or antibiotics, allergies to study medications, smoking, pregnancy, breastfeeding, or participation in another clinical trial.

Design outcomes

Primary

Measure	Time frame
Combining vitamin C and zinc with antibiotics significantly enhanced bacterial clearance, reduced inflammatory cytokine expression, and accelerated clinical recovery in CABP compared to antibiotics alone.	—

Secondary

Measure	Time frame
Antibiotic course duration was shortest in Ab+VC+Z (median; 6 days) compared to Ab+VC (median; 8 days) and Ab (median; 10 days, p < 0.001).	—

Countries

Egypt

Contacts

Public ContactSafaa Hammad

Faculty of Medicine

Safaa.Hammad@mu.edu.eg01060870431

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026