Respiratory
Conditions
Interventions
Pressure support ventilation
Sponsors
Ain Shams university hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: *Age =18 years. *Admitted with acute respiratory failure (ARF). *On mechanical ventilation with Puritan–Bennett 840 ventilator for =24 hours. *Considered for weaning after improvement or resolution of underlying cause. *Fully conscious.*Minimal or no requirement for vasoactive drugs or sedation. *Adequate gas exchange (PaO2/FiO2 >200 at PEEP 5 cmH2O and FiO2 <0.5)Rapid shallow breathing index (RSBI) <105 breaths/min/L.
Exclusion criteria
Exclusion criteria: *Age 64 *Hemodynamic instability requiring high-dose vasoactive support. *Persistent altered level of consciousness.*Ongoing sedation.*Severe metabolic or electrolyte disturbances. *Morbid obesity (BMI =40 kg/m²). *Tracheostomy .*Pregnancy .*Refusal to participate by patient or legal guardian.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in PaO2/FiO2 ratio (oxygenation index) during spontaneous breathing trial | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in Respiratory Rate to Tidal Volume Ratio (RR/VT) Change in Oxygen Saturation (SpO2) Change in Dynamic Compliance Change in Airway Resistance Change in Intrinsic PEEP Change in Arterial Oxygen Tension (PaO2) Change in Arterial Carbon Dioxide Tension (PaCO2) Extubation Success Rate | — |
Countries
Egypt
Contacts
Public ContactAhmed Al Elshebiny
Ain Shams university
Outcome results
None listed