Studying the effect of low volume versus standard volume of local anesthetic on phrenic nerve function in ultrasound guided upper trunk block in shoulder surgeries

Effect of Low Versus Standard Local Anesthetic Volumes on Phrenic Nerve Function in Ultrasound Guided Upper Trunk Block in Shoulder Surgeries

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

PACTR

Registry ID

PACTR202510543542850

Enrollment

Registered

2025-10-10

Start date

2024-03-07

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

Low volume group

High volume group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Age: between 18 - 50 years of age. American Society of Anesthesiologists physical status: I- II. Body mass index: 18-35 kg.m-2.

Exclusion criteria

Exclusion criteria: Allergy to local anesthetic agents. Skin infection at the site of injection. Coagulopathy. Cervical cord Pathology. Neuromuscular diseases. Chronic Obstructive Pulmonary Disease. Addicts. Chronic analgesics.

Design outcomes

Primary

Measure	Time frame
The primary outcome of this study is to detect phrenic nerve palsy in upper trunk nerve block using different volumes of Bupivacaine (low volume vs high volume).	—

Secondary

Measure	Time frame
The intensity of postoperative pain using (VAS score). ;Duration of analgesia, defined as the time to first post operative analgesic rescue (nalbuphine Hcl 0.05mg/kg IV). ;Total dose of post operative analgesic requirement. ;The degree of sparing of motor power of the upper limb. Motor block is evaluated by shoulder abduction (axillary nerve, C5) and shoulder external rotation (suprascapular nerve, C6), Handgrip is evaluated by asking the patient to make a fist and squeeze the assessor’s fingers. It is graded on a three-point scale (2 = normal; 1 = weakness; and 0 = complete loss of power).; The adverse effects of upper trunk nerve block using ultrasound guided technique including local anesthetic toxicity, hemodynamic instability, hematoma at the site of injection, and pneumothorax.	—

Measure

Time frame

The intensity of postoperative pain using (VAS score). ;Duration of analgesia, defined as the time to first post operative analgesic rescue (nalbuphine Hcl 0.05mg/kg IV). ;Total dose of post operative analgesic requirement. ;The degree of sparing of motor power of the upper limb. Motor block is evaluated by shoulder abduction (axillary nerve, C5) and shoulder external rotation (suprascapular nerve, C6), Handgrip is evaluated by asking the patient to make a fist and squeeze the assessor’s fingers. It is graded on a three-point scale (2 = normal; 1 = weakness; and 0 = complete loss of power).; The adverse effects of upper trunk nerve block using ultrasound guided technique including local anesthetic toxicity, hemodynamic instability, hematoma at the site of injection, and pneumothorax.

—

Countries

Egypt

Contacts

Public ContactAly Moustafa

Assistant professor of anesthesia

a_ahmed00@alexmed.edu.eg+21224129850

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026