Effect of IV infusions of Dexmedetomidine VS Fentanyl on perioperative hemodynamics and quality of emergence in patients undergoing partial or hemiglossectomy

Effect of IV infusions of Dexmedetomidine VS Fentanyl on perioperative hemodynamics and quality of emergence in patients undergoing partial or hemiglossectomy, Double Blinded Comparative Study

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

PACTR

Registry ID

PACTR202509822488978

Enrollment

Registered

2025-09-09

Start date

2024-01-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

Intravenous dexmedetomidine infusion

Intravenous fentanyl infusion

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Age between 18-60 years ASA II or III Scheduled for partial or hemi-glossectomy

Exclusion criteria

Exclusion criteria: Emergency cases or advanced tumors requiring awake fiberoptic intubation Pregnancy or lactation Known sensitivity or contraindication to drug used in the study (opioids, dexmedetomidine) Acute or chronic renal failure Compromised cardiovascular function Severe respiratory disorder Severe deranged liver function ASA IV Hemodynamic instability Uncontrolled systemic disease Use of alpha blockers Heart rate below 55 beats/min

Design outcomes

Primary

Measure	Time frame
Quality of emergence (sedation) according to Modified Ramsay Sedation Score	—

Secondary

Measure	Time frame
Total amount of fentanyl/dexmedetomidine consumed intraoperatively;Hemodynamic changes (heart rate, mean arterial pressure);Postoperative pain scores (Numeric Rating Scale);Postoperative nausea and vomiting;Time to first rescue analgesia;Drug-related complications (hypotension, bradycardia, respiratory depression, urinary retention, pruritus);Patient satisfaction (5-point scale)	—

Countries

Egypt

Contacts

Public ContactMariam Abdelsalam

Department of Anesthesia Surgical ICU and Pain Management National cancer institute Cairo University

Maryooma-h-2010@hotmail.com+201007623087

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026