Cancer
Conditions
Interventions
dysphagia optimized intensity modified radiotherapy
standard intensity modulated radiotherapy
Sponsors
Tanta university Faculty of medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: • Age = 18 years. • Patient treated with radiotherapy for HNC (squamous cell carcinoma). • Disease of T1 to T4, N0 to N3, and non-metastatic disease. • CCRT is the planned treatment. • Radiation alone was also allowed. • Adequate cognitive ability to complete assessment questionnaires
Exclusion criteria
Exclusion criteria: • Records demonstrating a history of swallowing difficulties unrelated to HNC. • Prior radiation treatment to the head and neck area. • Involvement of retropharyngeal node, posterior pharyngeal wall or post cricoid. • Major surgery excluding biopsy or tonsillectomy. • History of tracheostomy insertion. • Any proven cancer occurred within the last 2 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| determine whether reducing the radiation dose to pharyngeal constrictors using Do-IMRT, would improve swallowing function compared to S-IMRT in HNC patients treated with radical chemo-radiation or radiation alone. | — |
Secondary
| Measure | Time frame |
|---|---|
| Investigate the longitudinal pattern of patient reported swallowing function post radiotherapy treatment using the MDADI; ? Investigate the impact of using Do-IMRT on (i) Normalcy of diet and public eating using the PSS HN scale; (ii) Swallowing performance using the 100 mL Water Swallow Test; (iii) Acute and late toxicity using NCI CTCAE v5.0. ? Assess patient-reported QoL and priority concerns using the UW-QoL questionnaire (v.04). Radiological assessment by CT or MRI was requested 6 weeks post radiotherapy, and RECIST was applied. | — |
Countries
Egypt
Contacts
Public Contactnehal elmashad
Clinical oncology department Faculty of medicine Tanta university
Outcome results
None listed