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Randomized Clinical Trial: Injection site and ocular pain severity association following intravitreal Bevacizumab injection among Ghanaian patients.

Randomized Clinical Trial: Injection site and ocular pain severity association following intravitreal Bevacizumab injection among Ghanaian patients.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
PACTR
Registry ID
PACTR202509546846290
Enrollment
60
Registered
2025-09-29
Start date
2025-05-01
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eye Diseases

Interventions

Superior nasal quadrant injection of 1.25 mg in 0.05ml Intravitreal Bevacizumab injection
Intravitreal Bevacizumab injection at the Superior Temporal quadrant of ocular surface
Intravitreal Bevacizumab injection at the Inferior temporal quadrant of the ocular surface
Intravitreal Bevacizumab injection at the Inferior nasal quadrant of the ocular surface

Sponsors

Alex Kweku Addo
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1. The patient must be more than 18 years old. 2. The patient must have their diagnosis confirmed by a specialist or consultant Ophthalmologist. 3. The patient must have been scheduled to receive IVI of Bevacizumab

Exclusion criteria

Exclusion criteria: Exclusion Criteria 1. A patient who has had any previous intravitreal injections. 2. A patient with a pre-procedure IOP of > 21 mmHg. 3. A patient on systemic pain analgesics or topical analgesics or sedatives. 4. A patient on topical IOP lowering drugs. 5. A patient with a history of herpetic ocular infection. 6. A patient with an anterior segment condition that could affect pain sensation, such as conjunctival irritation, active conjunctivitis or keratitis or bullous keratopathy. 7. A patient who cannot see the VAS with the contralateral eye. 8. A patient who does not understand how to use the VAS.

Design outcomes

Primary

MeasureTime frame
The association between the pain score and the site of injection of Bevacizumab.

Secondary

MeasureTime frame
The self-reported pain scores after IVI of Bevacizumab. ;Factors associated with self-reported pain after IVI of Bevacizumab. ;IOP variations after IVI of Bevacizumab. ;Association between the reported pain and the intraocular pressure change after IVI of Bevacizumab

Countries

Ghana

Contacts

Public ContactAlex Kweku Addo

Specialist Ophthalmologist at Korle BU teaching Hospital

alexkwekuaddo@gmail.com+233240753682

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026