Intrathecal dexmedetomidine and prevention of post-dural puncture headache in females undergoing elective cesarean section under spinal anesthesia: a randomized double-blind trial

Intrathecal dexmedetomidine and prevention of post-dural puncture headache in females undergoing elective cesarean section under spinal anesthesia

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

PACTR

Registry ID

PACTR202509503374857

Enrollment

Registered

2025-09-02

Start date

2025-09-10

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia

Interventions

Intrathecal Dexmedetomidine plus Bupivacaine

Intrathecal Bupivacaine plus Normal Saline

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Age (18-40 years) ASA ll Singleton, full term pregnant females BMI (18.5-30) kg m-2 Scheduled for elective caesarean section under spinal anesthesia

Exclusion criteria

Exclusion criteria: Refusal of spinal anesthesia Known or suspected coagulopathy (international normalized ratio > 1.4 / thrombocytopenia with platelet count < 100,000) Known peripheral neuropathy, neurological deficits or skeletal deformities Multiple attempts for spinal anesthesia Known allergy to dexmedetomidine or bupivacaine History of migraine headache, hypertensive disorders of pregnancy Infection at site of injection Refusal to sign informed consent Patients with more than one single attempt ? Patients with uncontrolled cardiac morbidities (patients with tight valvular lesion, impaired contractility with ejection fraction less than 50%, heart block and arrhythmias), hypertensive disorders of pregnancy, peripartum bleeding

Design outcomes

Primary

Measure	Time frame
Incidence of post-dural puncture headache	—

Secondary

Measure	Time frame
Severity of post-dural puncture headache (VAS > 6) and number of headache episodes;Incidence of intraoperative and postoperative nausea and vomitig;Incidence of postoperative pruritus;Incidence of adverse effects (hypotension, bradycardia, apnea, nausea, shivering, block failure, pain during surgery).;Effect on newborns (APGAR score).	—

Countries

Egypt

Contacts

Public ContactMohammed Nady

Department of Anesthesia Surgical ICU and Pain Management Faculty of Medicine Cairo University

M.N.K94@hotmail.com+201018837635

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026